Anti-Cyclin L2 (isoform 1)

Cyclin L2 (isoform 1)

Human Cyclin L2? 520 aa predicted MW 58. 1 kDa1 MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE NCLLPDDKLR61 FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA TGQVLFQRFF YTKSFVKHSM121 EHVSMACVHL ASKIEEAPRR IRDVINVFHR LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE181 RRVLKELGFC VHVKHPHKII VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI241 ACACIYLAAR TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK301 RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL SVKNTKRRLE361 GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS PKRRKSDSGS TSGGSKSQSR421 SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK DCKYPQKPHK SRSRSSSRSR SRSRERADNP481 GKYKKKSHYY RDQRRERSRS YERTGRRYER DHPGHSRHRR Family: Cell Cycle Fraction: Affinity Purified IgG

ELISA 1:2 000 - 1:10 000WESTERN BLOT 1:500 - 1:3 000IF MICROSCOPY User OptimizedOTHER APPLICATIONS User OptimizedPhysical State: Liquid (sterile filtered)Purity and

1. 0 mg/ml (by UV absorbance at 280 nm)

Dry Ice Cyclin L (also referred to as CCNL) isencoded by two highly related genes Cyclin L1 andCyclin L2 (CCNL1 and CCNL2 respectively). Cyclin L2can be alternatively spliced to produce two isoforms(known as 1 and 2 or alpha and beta). The Cyclin L2gene is located approximately 100-200 kb from thePITSLRE/CDK11 protein kinase locus in human (1p36)and in a syngenetic location on mouse chromosome4q. Cyclin L2 is ubiquitous expressed at much higherlevels than Cyclin L1 and thus is likely the majorpartner for the CDK11p110 protein kinase. Loyera P. Trembleya J. H. Katonac R. Kidd V. J. and Lahtia J. M. (2005) Role of CDK/cyclin complexes in transcription and RNA splicing. Cell. Signal. 17; 1033 - 1051. Sticht C. Hofele C. Flechtenmacher C. Bosch F. X. Freier K. Lichter P. and Joos S. (2005) Amplification of Cyclin L1 is associated withlymph node metastases in head and neck squamous cell carcinoma (HNSCC). Br. J. Cancer 92 (4) 770-774. Dickinson L. A. Edgar A. J. Ehley J. and Gottesfeld J. M. (2002) Cyclin L is an RS domain protein involved in pre-mRNA splicing. J. Biol. Chem. 277 (28) 25465-25473. Yang L. Li N. Wang C. Yu Y. Yuan L. Zhang M. and Cao X. (2004) Cyclin L2 a novel RNA polymerase II-associated cyclin is involved inpre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. J. Biol. Chem. 279 (12) 11639-11648. Berke J. D. Sgambato V. Zhu P. P. Lavoie B. Vincent M. Krause M. and Hyman S. E. (2001) Dopamine and glutamate induce distinct striatalsplice forms of Ania-6 an RNA polymerase II-associated cyclin. Neuron 32 (2) 277-287. Cheng H. and Bjerknes M. (1996) Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium. Anat. Rec. 244 (1) 78-94.