DR3


ArtNr	18-783-313091
Hersteller	GENWAY
Menge	0,05 mg
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-73D54E
Similar products	18-783-313091
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Genway ID:	GWB-73D54E
Specificity:	DR3
Specificity:	DR3
Immunogen:	Peptide sequence QGGTRSPRCDCAGDFH from amino terminus of human DR3
Antiserum Preparation:	Antisera to DR3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02%Sodium AzideSuggested
Dilution:	Suggested
Dilution:	Western Blotting - 1/500 - 1/1000
Function:	Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Subunit:	Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades apoptosis and NF-kappa-B signaling. Interacts with BAG4.
Subcellular Location:	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 2: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 9: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 11: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 3: Secreted.
Subcellular Location:	Isoform 4: Secreted.
Subcellular Location:	Isoform 5: Secreted.
Subcellular Location:	Isoform 6: Secreted.
Subcellular Location:	Isoform 7: Secreted.
Subcellular Location:	Isoform 8: Secreted.
Subcellular Location:	Isoform 10: Secreted.
Subcellular Location:	Isoform 12: Secreted.
Tissue Specificity:	Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus colon intestine and spleen. Also found in the prostate.
Ptm:	Glycosylated (Probable).
Similarity:	Contains 1 death domain.
Similarity:	Contains 4 TNFR-Cys repeats. 1. Chinnaiyan. A. M. et al. (1996) Signal transduction by DR3. a death domain-containing receptor related to TNFR-1 and CD95. 2. Marsters. S. A. et al. (1998) Identification of a ligand for the death-domain containing receptor Apo-3.

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Menge: 0,05 mg

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