CASPASE-7


ArtNr	18-783-313126
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-BE07D0
Similar products	18-783-313126
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Genway ID:	GWB-BE07D0
Specificity:	CASPASE-7 NCBI
Gene ID:	840
Specificity:	CASPASE-7
Immunogen:	A 16 amino acid peptide from human Caspase-7 carboxy-terminus
Immunohistology:	This product does not require protein digestion pre-treatment of paraffin sections eg. Trypsin or pronase prior to staing. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Histology: Skeletal muscle tissue
Antiserum Preparation:	Antisera to human Caspase-7 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 02%Sodium AzideSuggested
Dilution:	Suggested
Dilution:	Immunohistology - Paraffin - 2. 0ug/mlWestern Blotting - 1. 0ug/ml - 2. 0ug/ml
Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a \' 216-Asp-\|-Gly-217\' bond. Overexpression promotes programmed cell death.
Catalytic Activity:	Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-\|-.
Enzyme Regulation:	Inhibited by isatin sulfonamides.
Subunit:	Heterotetramer that consists of two anti-parallel arranged heterodimers each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
Subcellular Location:	Cytoplasm.
Tissue Specificity:	Highly expressed in lung skeletal muscle liver kidney spleen and heart and moderately in testis. No expression in the brain.
Ptm:	Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3 and vice versa also occur.
Similarity:	Belongs to the peptidase C14A family [view classification]. 1. Duan. H. et al. (1996) ICE-LAP3. a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. 2. Juan. T. S. et al. (1997) Identification and mapping of Casp7. a cysteine protease resembling CPP32 beta. interleukin-1 beta converting enzyme. and CED-3. 3. Cohen. G. M. (1997) Caspases: the executioners of apoptosis.

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