RABBIT ANTI op18 (C-TERMINAL)

op18 (C-TERMINAL)

Phosphate buffered saline

A 20 amino acid peptide located near the carboxy terminus of human op18.

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear By similarity. Subunit structureBinds to two alpha/beta-tubulin heterodimers. Interacts with KIST. Ref. 15Ref. 16Subcellular locationCytoplasm. Tissue specificityUbiquitous. Expression is strongest in fetal and adult brain spinal cord and cerebellum followed by thymus bone marrow testis and fetal liver. Expression is intermediate in colon ovary placenta uterus and trachea and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes non-leukemic proliferating lymphoid cells bone marrow cells or cells from patients with chronic lymphoid or myeloid leukemia. Ref. 3Ref. 18Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level). Ref. 22Post-translational modificationMany different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Ref. 11Ref. 12Ref. 13Ref. 14Ref. 17Ref. 19Ref. 20Ref. 21Ref. 23Ref. 24Ref. 25Ref. 26Ref. 27Ref. 28Ref. 29Ref. 31Ref. 32Sequence similaritiesBelongs to the stathmin family.