RABBIT ANTI MD-2

MD-2

Phosphate buffered saline

A peptide corresponding to amino acids near the middle of human MD-2.

Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS) and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4 but not TLR4 alone respond to LPS. Subunit structureHeterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor a multi-protein complex containing at least CD14 LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. Ref. 7Ref. 8Ref. 9Ref. 11Subcellular locationSecreted & rsaquo; extracellular space. Post-translational modificationN-glycosylated; high-mannose. Ref. 8Ref. 11 1. Cobbold S. & Metcalfe S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 43: 137-154. 2. Reis A. B. et al. (2006) Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Clin Exp Immunol. 146: 303-11.