RABBIT ANTI PPAR DELTA

PPAR DELTA

Phosphate buffered saline pH7. 2

Synthetic peptide corresponding to amino acids 1 -14 of mouse PPAR delta.

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand By similarity. Subunit structureHeterodimer with the retinoid X receptor. Subcellular locationNucleus. Tissue specificityHeart adrenal and intestine. Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Sequence cautionThe sequence AAA03332. 1 differs from that shown. Reason: Erroneous initiation. 1. Honer W. G. et al. (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 609: 9-20. [1] \" Cloning and sequence analysis of a cDNA encoding human syntaxin 1A a polypeptide essential for exocytosis. \" Zhang R. -D. Maksymowych A. B. Simpson L. L. Gene 159:293-294(1995) [PubMed: 7622072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. [2] \" Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome. \" Osborne L. R. Soder S. Shi X. -M. Pober B. Costa T. Scherer S. W. Tsui L. -C. Am. J. Hum. Genet. 61:449-452(1997) [PubMed: 9311751] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2). [3] \" Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients. \" Wu Y. -Q. Bejjani B. A. Tsui L. -C. Mandel A. Osborne L. R. Shaffer L. G. Am. J. Med. Genet. 109:121-124(2002) [PubMed: 11977160] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2) SEQUENCE REVISION TO 144. [4] \" Novel isoform of syntaxin 1 is expressed in mammalian cells. \" Jagadish M. N. Tellam J. T. Macaulay S. L. Gough K. H. James D. E. Ward C. W. Biochem. J. 321:151-156(1997) [PubMed: 9003414] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Adipose tissue. [5] \" Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11. 2. \" Nakayama T. Fujiwara T. Miyazawa A. Asakawa S. Shimizu N. Shimizu Y. Mikoshiba K. Akagawa K. Genomics 42:173-176(1997) [PubMed: 9177791] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [6] \" The DNA sequence of human chromosome 7. \" Hillier L. W. Fulton R. S. Fulton L. A. Graves T. A. Pepin K. H. Wagner-McPherson C. Layman D. Maas J. Jaeger S. Walker R. Wylie K. Sekhon M. Becker M. C. O\' Laughlin M. D. Schaller M. E. Fewell G. A. Delehaunty K. D. Miner T. L. 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Green E. D. Waterston R. H. Wilson R. K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain and Lung. [8] \" Human syntaxin is homologous with rat syntaxin A and digested by BoNT C. \" Zhang R. -D. Simpson L. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-288 (ISOFORM 1). Tissue: Brain. [9] \" Expression analysis of the human HPC-1/syntaxin 1A a gene deleted in Williams syndrome. \" Botta A. Calza L. Giardino L. Potenza S. Novelli G. Dallapiccola B. Genomics 62:525-528(1999) [PubMed: 10644452] [Abstract]Cited for: TISSUE SPECIFICITY. [10] \" Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. \" Polgar J. Chung S. H. Reed G. L. Blood 100:1081-1083(2002) [PubMed: 12130530] [Abstract]Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8 AND SNAP23.