URACIL-DNA GLYCOSYLASE 2

URACIL-DNA GLYCOSYLASE 2 NCBI

URACIL-DNA GLYCOSYLASE 2

This product recognises uracil DNA glycosylase 2 (UNG2) a 38 kDa member of the cyclin family expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG2 is a major enzyme in base excision repair excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase UNG2 is also essential to the generation of strand breaks that initiate class switch recombination. UNG2 is also involved in the innate immune response against retroviral infections HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.

Phosphate buffered saline

Western Blot: This product detects a band of approximately 38kDa in mouse bladder tissue lysate. Suggested

Excises uracil residues from DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.