FEN1


ArtNr	18-783-76627
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB, IP
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5BB6C0
Similar products	18-783-76627
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Genway ID:	GWB-5BB6C0
Specificity:	FEN1NCBI
Gene ID:	2237
Specificity:	FEN1
Immunogen:	Synthetic peptide corresponding to a region within the N terminal domain of human FEN1 (locus link ID 2237)
Specificity Note:	This product is specific for human flap structure-specific endonuclease 1 (FEN1). FEN1 is a member of the XPG/RAD2 endonuclease family which has an important role in lagging strand DNA synthesis and base excision repair. It is hypothesised that FEN1 may play a role in the inhibltion of triplet repeat expansion.
Antiserum Preparation:	Antisera to human FEN1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	TRIS-citrate/phosphate pH7. 5
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Dilution:	Western Blot: This product detects a band of approximately 42kD in Hela cell lysates. Suggested
Dilution:	Immunoprecipitation - 4ug/mg protein - 10ug/mg proteinWestern Blotting - 1:5000 - 1:30000
Function:	Endonuclease that cleaves the 5\' -overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5\' -end of a downstream Okazaki fragment. Also possesses 5\' to 3\' exonuclease activity on niked or gapped double-stranded DNA and exhibits RNase H activity.
Subunit:	Interacts with PCNA. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300.
Subcellular Location:	Nucleus.
Ptm:	Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
Similarity:	Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

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Menge: 0.1 mg

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