GABA A RECEPTOR BETA 1

GABA A RECEPTOR BETA 1NCBI

GABA A RECEPTOR BETA 1

This product is specific for the beta 1 subunit of rat gamma-aminobutyric acid A (GABAA) receptor. GABAA receptors are GABA gated chloride channels which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified which show distinct patterns of temporal and spatial expression. GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).

10mM HEPES pH7. 5

Western Blot: This product detects a band of approximately 55kDa in rat cerebellar lysates. Suggested

GABA the major inhibitory neurotransmitter in the vertebrate brain mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Cell junction synapse postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.