GROWTH HORMONE


ArtNr	18-783-78957
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Metabolism Diabetes Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E31F92
Similar products	18-783-78957
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Genway ID:	GWB-E31F92
Specificity:	GROWTH HORMONE
Specificity:	GROWTH HORMONE
Immunogen:	Purified rat growth hormone
Specificity Note:	This product is specific for rat growth hormone (GH) which acts to control body growth and metabolic activity. GH is a small peptide hormone released by the anterior pituitary under the control the hypothalamus. This antibody does not react with rat LH TSH FSH or prolactin.
Preparation:	Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution:	0. 05 M NH4HCO3
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunohistology - Frozen - 1/200 - 1/500Western Blotting - 1/300 - 1/400
Function:	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Subunit:	Monomer dimer trimer tetramer and pentamer disulfide-linked or non-covalently associated in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.
Subcellular Location:	Secreted.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which causes short stature.
Disease:	Defects in GH1 are the cause of Kowarski syndrome [MIM:262650]; also known as pituitary dwarfism VI.
Disease:	Defects in GH1 are a cause of isolated growth hormone deficiency type II (IGHD II) [MIM:173100]. IGHD II is an autosomal dominant deficiency of GH which causes short stature.
Disease:	Defects in GH1 may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth. Pharmaceutical: Available under the names Nutropin or Protropin (Genentech) Norditropin (Novo Nordisk) Genotropin (Pharmacia Upjohn) Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner\' s syndrome.
Miscellaneous:	Circulating GH shows a great heterogeneity due to alternative splicing differential post-translational modifications of monomeric forms oligomerization optional binding to 2 different GH-binding proteins and potentially proteolytic processing.
Similarity:	Belongs to the somatotropin/prolactin family.

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