GluR1

GWB-785FB4

A synthetic peptide corresponding to residues near N-terminus of human Glutamate receptor 1 was used as immunogen. Predicted to cross-react with rat based on sequence homology.

WB: 1:1000IHC: 1:50IP: 1:30. Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1 human glutamate receptor type 1 is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). 1. Baba T Nakamoto Y Mukaida N Crucial Contribution of Thymic Sirp+ Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner J. Immunol. 183 (2009) 3053 - 3063[Application: ]2. van Vuurden DG Yazdani M Bosma I et al Attenuated AMPA Receptor Expression Allows Glioblastoma Cell Survival in Glutamate-Rich Environment PLoS One. 4 (2009) e5953[Application: IHC]1. Potier M. C. et al. The human glutamate receptor cDNA GluR1: cloning sequencing expression and localization to chromosome 5. DNA Seq. 2: 2112. Puckett C. et al. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc. Nat. Acad. Sci. USA 88: 75573. Gregor P. et al. Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans. Proc. Nat. Acad. Sci. USA 90: 30534. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487