C/EBP beta (C-term)

GWB-F43BBB

A synthetic peptide corresponding to residues in C-terminus of rat C/EBP b was used as immunogen. The antibody can recognize three C/EBPb isoform (i. e. LAP* LAP and LIP).

WB: 1:1 000ICC: 1:50-100IP: 1:20. CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (alpha beta gamma delta epsilon zeta ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-beta suggesting its activities are post-translationally regulated by cAMP (2). Even though it has been show that C/EBP beta occurs predominantly as a heterodimer (3) C/EBP beta & gamma readily heterodimerize with each other as well as with C/EBP alpha (4). 1. Julie Lekstrom-Himes and Kleanthis G. Xanthopoulos J Biol Chem Vol. 273 Issue 44 28545-28548 October 30 19982. Brasier AR and Li J. Mechanisms for Inducible Control of Angiotensinogen Gene Transcription. Hypertension 27:465-475 (1996). 3. Sara E. Parkin Mark Baer Terry D. Copeland Richard C. Schwartz and Peter F. Johnson J. Biol. Chem. Vol. 277 Issue 26 23563-23572 June 28 20024. H Thomassin D Hamel D Bernier M Guertin and L Belanger. Nucleic Acids Research Vol 20 Issue 12 3091-3098 19925. Wen-Chi Su et al. J. Biol. Chem. Vol. 278 Issue 51 51150-51158 December 19 20036. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487