PI3K p110beta

GWB-E1BB27

A synthetic peptide of human PI3-K p110 beta was used as an immunogen.

WB: 1:500FC: 1:40IP: 1:50. PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; a beta and the subunit (3). The beta isoform forms heterodimers with p85 subunit (4). p110-beta has a role in regulating the formation and stability of integrin adhesion bonds (alpha-2B and beta-3) which are necessary for shear force-induced platelet activation (5). 1. Kim YJ Ketter R Steudel WI et al Prognostic Significance of the Mitotic Index Using the Mitosis Marker Anti-Phosphohistone H3 in Meningiomas Am J Clin Pathol 128 (2007) 118 - 125[Application: ]1. Otsu M. Hiles I. D. Gout I. Fry M. J. Ruiz-Larrea F. Panayatou G. Thompson A. Dhand R. Hsuan J. Totty N. Smith A. D. Morgan S. J. Courtnidge S. A. Parker P. J. and Waterfield M. D. (1992) Cell 65 91-1042. Hiles I. D. Otsu M. Volinia S. Fry M. J. Gout I. Dhand R. Panayatou G. Ruiz-Larrea F. Thompson A. Totty N. F. Hsuan J. J. Courtnidge S. A. Parker P. J. and Waterfield M. D. (1991) Cell 70 419-4293. Hu P. Mondino A. Skolnik E. Y. and Schlessinger J. (1993) Mol. Cell. Biol. 13 7677-76884. Jackson et al. Nature Med. 11: 507-514 2005. 5. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487