Vitronectin

GWB-60C5BB

A synthetic peptide corresponding to residues near the V10 subunit of human vitronectin was used as an immunogen.

WB: 1:20 000IHC: 1:100-250ICC: 1:50-100. Vitronectin a 75 kDa polypeptide along with a 10 kDa fragment is a glycoprotein present on most cell surfaces in extracellular fluids and plasma (1). Vitronectin promotes cellular adhesion and spreading inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors (2). As a member of the integrin family Vitronectin contains the cell binding sequence arg gly asp (RGD) first found in fibronectin and serves as a cell-to-substrate adhesion molecule (3). Vitronectin acts as an inhibitor of the complement cascade by binding to the C5b9 complex and it has also been shown to have has a novel and direct role in self-senescent-self intercellular recognition leading to macrophage phagocytosis of cells undergoing apoptosis (4). 1. Rouslahti E et al. J Invest Dermatol 79:65-68 19822. Bauer JS et al. J Cell Biol. 116(2):477-87 19923. Stefansson S et al. Nature 383(6599):390-1 19964. Savill J et al. Nature 343:170-3 19905. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487