Cytokeratin 10

GWB-8027D0

A synthetic peptide corresponding to residues in the C-term of human Cytokeratin 10 was used as immunogen.

WB: 1:1 000 - 10 000IHC: 1:100 - 250ICC: 1:100 - 250IP: 1:30. Cytokeratin 10 (CK10) is a heterotetramer of two type I and two type II keratins. CK10 is typically associated with cytokeratin 1 (CK1). CK10 is expressed in all suprabasal cell layers and it is part of acidic/high molecular weight keratin subfamily. Defects in CK10 causes Epidermolytic hyperkeratosis (EHK) a hereditary skin hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum (1). CK10 has also been linked to cause of annular epidermolytic ichthyosis (AEI) also known as cyclic ichthyosis with epidermolytic hyperkeratosis. CK10 along with CK14 15 16 and 20 can be used to determine if a neoplasm originated from an epithelial or non-epithelia origin such as the determination of metastatic malignant tumors of epithelial origin (2). 1. Shivshankar P Sanchez C Rose LF et al The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells Mol Microbiol 73 (2009) 663-679[Application: WB IP]1. McGowan K et al; Journal of Investigative Dermatology 126:10132. Lin Y et al; Modern Pathology 17:11293. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487