Filamin A (C-term)

GWB-8D7BE4

A synthetic peptide corresponding to residues near the C-terminus of human Filamin A was used as an immunogen.

WB: 1:250 000 - 500 000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:40. Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous actin in networks and stress fibers. Recently it has become clear that filamins anchor various transmembrane proteins to the actin cytoskeleton and provide a scaffold for a wide range of cytoplasmic signaling proteins (1). Actin-binding protein (Filamin A) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm where it promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins (2). The actin-binding domain is near the amino-terminus of the subunit where the amino acid sequence is similar to other actin filament binding proteins including alpha-actinin beta-spectrin dystrophin and Dictyostelium abp-120. A monoclonal antibody recognizing Filamin A and Fh1 binds to blood vessels astrocytes neurofibrillary tangles neuropil threads and dystrophic neurites in the AD brain. Detection of Filamin A /Fh1 proteins in these structures suggests that these presenilin-interacting proteins may be involved in the development of Alzheimer\' s disease and that interactions between presenilins and Filamin A /Fh1 may be functionally significant (3). 1. van der Flier A. Biochim Biophys 1538(2):99-117 20012. Gorlin JB et al. J Cell Biol 111(3):1089-105 19903. Zhang W et al. J Neurosci 18(3):914-22 1998. 4. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487