AE1 Phospho (pY359)

EPR2668Y

WB: 1:50 000. The AE1 (anion exchanger band 3) protein is expressed in erythrocytes and in the A-type intercalated cells of the kidney distal collecting tubule. In both cell types it mediates the electroneutral transport of chloride and bicarbonate ions across the lipid bilayer and in erythrocytes (1). AE1 is phosphorylated on Tyr359 and Tyr404 by Lyn in erythrocytes. Phosphorylation of these residues is necessary for correct localization and recycling of kidney AE1 to the basolateral membrane (2). 1. Sahr KE et al. Genomics 24(3):491-501 19942. Toye AM et al. Biochem Soc Symp 72:47-63 20053. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487