Apolipoprotein A-II (ApoA-II)

GWB-FA83B0

A synthetic peptide corresponding to residues in human Apolipoprotein A-II (ApoA-II) was used as an immunogen.

WB: 1:1 000 - 5 000ICC: 1:100 - 250FC: 1:50. Apolipoprotein A II is the second most abundant protein of the high density lipoprotein particles accounting for 20% of protein mass of HDL. The concentration of ApoA-I and ApoA-II is inversely correlated with the frequency of heart disease in human (1). In studies with mice and humans ApoA-II levels have been associated with increased susceptibility to atherosclerosis increased free fatty acid levels increased body fat and increased insulin resistance (2). ApoA-II consists of three potential amphipathic helices of 17 residues each which contribute to the lipid-binding properties of this apolipoprotein (3). Currently the best characterized activity of apoA-II is its potent antagonism of the anti-atherogenic and anti-inflammatory activities of ApoA-I probably due to its competition with the latter for lipid acyl side chains of HDL (1). 1. Kumar et al. Biochemistry. 41 (39):11681-11691 20022. Castellani and Lusis. Arterioscler. Thromb. Vasc. Biol. 2. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487