NF-M

IGG
ArtNr	20-271-80104
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot Primary Antibodies By Organ Brain Cancer Schwann Cell Markers
Typ	Antibody
Applikationen	WB
Clon	A00145. 01
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-7C0DB1
Similar products	20-271-80104
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Genway ID:	GWB-7C0DB1
Clone:	A00145. 01
Subclass:		Mouse Monoclonal
Specificity:	NF-M from human. rat. mouse. cat. chicken.
Application:	ELISA and Western Blot. Staining antibody. weakly cytotoxic. For staining. use 10 ul/106 cells. Titer for cytotoxicity should be determined by the investigator. Neurofilaments are the 10 nm or intermediate filament proteins found specifically in neurons. and are composed predominantly of three major proteins called NF-L. NF-M and NF-H. NF-M is the middle or medium neurofilament subunit and runs on SDS-PAGE gels i
Function:	Neurofilaments usually contain three intermediate filament proteins: L M and H which are involved in the maintenance of neuronal caliber.
Ptm:	There are a number of repeats of the tripeptide K-S-P NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Ptm:	Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H) the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
Similarity:	Belongs to the intermediate filament family. [1] Myers M. W. Lazzarini R. A. Lee V. M. Schlaepfer W. W. and Nelson D. L. The human mid-size neurofilament
Subunit:	a repeated protein sequence and the relationship of its gene to the intermediate filament gene family[2] Lazzarini R. A. et al. Direct Submission[3] Myers M. W. Lazzarini R. A. Lee V. M. -Y. Schlaepfer W. W. Nelson D. L. The human mid-size neurofilament
Subunit:	a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. [4] Lee V. M. -Y. Otvos L. Jr. Carden M. J. Hollosi M. Dietzschold B. Lazzarini R. A. Identification of the major multiphosphorylation site in mammalian neurofilaments. [5] DeGiorgis J. A. Jaffe H. Moreira J. E. Carlotti C. G. Jr. Leite J. P. Pant H. C. Dosemeci A. Phosphoproteomic analysis of synaptosomes from human cerebral cortex.

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