TAP1 [53H8]

53H8

Unfortunately this information is considered to be commercially sensitive

Cell Membrane

0. 1% Sodium Azide; Constituents: PBS

63 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein which binds the TAP complex and acts as a tapasin inhibitor preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections often beginning in the first decade of life are restricted to the respiratory tract.

Contains 1 ABC transmembrane type-1 domain.