E2F3 [PG30]

ArtNr	20-272-190641
Hersteller	GENWAY
Menge	0.1 ml
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB, IP
Clon	PG30
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-C2A69E
Similar products	20-272-190641
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Genway ID:	GWB-C2A69E
Clone:	PG30
Isotype:	IgG2a
Immunogen:	Recombinant protein (Human).
Antigen Species:	Human
Specificity:	Does not detect the other members of the E2F family.
Target:	E2F3
Localization:	Nuclear
Concentration:	2. 1 mg/ml Storage
Preservative:	15mM Sodium Azide; Constituents: 1% BSA 0. 01M PBS. pH70 7. 4
Application Note:	GSA: Use at an assay dependent dilution. IP (denatured): Use at an assay dependent dilution. WB: Use at a concentration of 4 - 8 µ g/ml. This concentration is determined using whole extract of transfected 293T (human embryonal kidney) cells expressing E2F3. Detects a band of approximately 57 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear E2F transcription factors are functionally regulated by binding to Rb p110 p107 and p130. E2F 3 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides.
Function:	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site 5\' -TTTC[CG]CGC-3\' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein in a cell-cycle dependent manner.
Subunit:	Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.
Subcellular Location:	Nucleus.
Similarity:	Belongs to the E2F/DP family.

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