LEF1 [1C3]

ArtNr	20-272-190705
Hersteller	GENWAY
Menge	0.025 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	WB
Clon	1C3
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-59C309
Similar products	20-272-190705
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Genway ID:	GWB-59C309
Clone:	1C3
Isotype:	IgG1
Immunogen:	Recombinant full-length human LEF-1 protein.
Antigen Species:	Human
Target:	LEF1
Localization:	Nuclear
Concentration:	1 mg/ml
Purification Note:	From mouse ascitic fluid Storage
Buffer:	0. 01M Phosphate-buffered saline pH 7. 5 containing 0. 08% sodium azide
Application Note:	WB: Use at a concentration of 1 - 5 µ g/ml. Predicted MW 55-57 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear Lymphoid enhancer factor LEF1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1 TCF1 TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer melanoma and breast cancer.
Function:	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1 TLE2 TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.
Subunit:	Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300 TLE1 and PIASG (By similarity). Binds THOC4 MDFI and MDFIC.
Subcellular Location:	Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity).
Tissue Specificity:	Detected in thymus. Not detected in normal colon but highly expressed in colon cancer biopsies and colon cancer cell lines.
Domain:	Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.
Similarity:	Belongs to the TCF/LEF family.
Similarity:	Contains 1 HMG box DNA-binding domain.

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Menge: 0.025 mg

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