CD4 [Q4120]

ArtNr	20-272-190839
Hersteller	GENWAY
Menge	50 TESTS
Kategorie	Oncology Antibodies Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Clon	Q4120
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D9CEC0
Similar products	20-272-190839
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Genway ID:	GWB-D9CEC0
Clone:	Q4120
Isotype:	IgG1
Immunogen:	CD4-transfected mouse T-cell hybridoma 3DT followed by CD4+ human T-cell CEM cells.
Antigen Species:	Human
Target:	CD4
Localization:	Cell Membrane
Concentration:	0. 05 mg/ml Storage
Preservative:	15mM Sodium Azide; Constituents: 1% BSA 0. 01M PBS. pH 7. 4
Application Note:	FACS: Use 5µ l for 10^6 cells. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane CD4 is a single chain transmembraneous glycoprotein which belongs to the immunoglobulin superfamily. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Menge: 50 TESTS

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