PIP [0.N.307]

0. N. 307

Recombinant protein encoding the excreted domain of human GCDFP15 (Human).

Skin

Cytoplasmic and Secreted Storage

IHC-P: Use at a dilution of 1/15 - 1/30. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Cytoplasmic and Secreted Gross cystic disease of the breast is benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive aporcine cystic secretions. This fluid is composed of several glycoproteins including a unique 15kD monomer protein PIP. Cytosolic analysis of normal tissue specimens from all major organs has demonstrated PIP in aporcine epithelia lacrimal ceruminous and Molls glands and in numerous serous cells of the submandibular tracheal bronchial sublingual and minor salivary glands. PIP and prostate specific antigen are co-expressed in androgen receptor-positive breast tumors.

Secreted (Probable).

By prolactin and androgen; inhibited by estrogen.