TdT [SPM149]

ArtNr	20-272-191185
Hersteller	GENWAY
Menge	0.5 ml
Kategorie	Oncology Antibodies By Cell Type Hematology Leukemia Cell Biology Cell Status Apoptosis Immunohistochemistry Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	IHC
Clon	SPM149
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-294FCC
Similar products	20-272-191185
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Genway ID:	GWB-294FCC
Clone:	SPM149
Isotype:	IgG2a
Immunogen:	Full length protein (Human).
Antigen Species:	Human
Positive Control:	Thymus.
Target:	TdT
Concentration:	tissue culture supernatant Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing 1% BSA and 0. 09% sodium azide
Application Note:	IHC-P: Use at a dilution of 1/25. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer pH 6. 0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. TdT is a nuclear enzyme involved in the recombination of Immunoglobulin and T cell receptor genes. TdT is expressed in early lymphoid cells and by tumour cells in certain classes of acute lymphoid leukaemia.
Function:	Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5\' -triphosphate to the 3\' -end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Catalytic Activity:	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Cofactor: Magnesium.
Subunit:	Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.
Subcellular Location:	Nucleus.
Disease:	Very high levels of enzyme activity have been detected in certain acute leukemic cells.
Similarity:	Belongs to the DNA polymerase type-X family.
Similarity:	Contains 1 BRCT domain.

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