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p73 alpha+beta [ER-15]

p73 alpha+beta [ER-15]

ArtNr	20-272-191433
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, IF, IP
Clon	ER-15
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5F126A
Similar products	20-272-191433
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Genway ID:	GWB-5F126A
Clone:	ER-15
Isotype:	IgG1
Immunogen:	Recombinant fragment corresponding to amino acids 380-637 of Monkey p73 alpha+beta.
Positive Control:	COS monkey kindey cells and IM9 human myeloma cells
Target:	p73 alpha+beta
Localization:	Nuclear
Concentration:	1 mg/ml Storage
Preservative:	0. 08% Sodium Azide. Constituents: PBS
Application Note:	GSA: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. IP: Use at a concentration of 2 µ g/mg. WB: Use at a concentration of 2 µ g/ml. Predicted
Molecular Weight:	70-80 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear This antibody does not cross-react with p53 or p53-related p51/Ket protein. This antibody binds to both p73a and p73b in immunoprecipitation and Western Blot assays.
Function:	Participates in the apoptotic response to DNA damage. When overproduced activates transcription from p53-responsive promoters and induces apoptosis. May be a tumor suppressor protein. Cofactor: Binds 1 zinc ion per subunit (By similarity).
Subunit:	The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Isoform Beta interacts homotypically and with p53/TP53 whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma isoform Alpha and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Found in a complex with p53/TP53 and CABLES1. Isoform Beta interacts with WWOX. Interacts with HECW2.
Subcellular Location:	Nucleus.
Tissue Specificity:	Brain kidney placenta colon heart liver spleen skeletal muscle prostate thymus and pancreas.
Induction:	Not induced by DNA damage.
Domain:	Possesses an acidic transactivation domain a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain.
Domain:	The WW-binding motif mediates interaction with WWOX.
Ptm:	Isoform alpha (but not isoform beta) is sumoylated on Lys-627 which potentiates proteasomal degradation but does not affect transcriptional activity.
Disease:	Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers in contrast to p53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.
Miscellaneous:	Activated and stabilized by interaction with RANBP9.
Similarity:	Belongs to the p53 family.

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Menge: 0.05 mg

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