Tropomyosin [SPM224]

SPM224

Full length native protein (purified) (Chicken).

Skeletal or cardiac muscle

Cytoplasmic

Phosphate-buffered saline pH 7. 4 containing BSA and sodium azide

Cytoplasmic Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a b 1 2 and 3) identified as such by their different apparent molecular masses after separation by SDS-PAGE but similar biochemical properties such as resistance to heat and organic solvents the ability to bind to F-actin filaments and the lack of proline and tryptophan.

Heterodimer of an alpha and a beta chain.

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues but not in skeletal muscle.

Defects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea syncope collapse palpitations and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Belongs to the tropomyosin family.