CD4 [MEM-241]

ArtNr	20-272-192194
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB
Clon	MEM-241
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-A2E86D
Similar products	20-272-192194
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Genway ID:	GWB-A2E86D
Clone:	MEM-241
Isotype:	IgG1
Immunogen:	Fusion protein (Human).
Antigen Species:	Human
Specificity:	This antibody is specific for CD4.
Target:	CD4
Localization:	Cell Membrane
Concentration:	1 mg/ml
Purification Note:	Purified from ascites by protein-A affinity chromatography. Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	FACS: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Use under non-reducing conditions. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane CD4 is a single chain transmembraneous glycoprotein which belongs to the immunoglobulin superfamily. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Menge: 0.1 mg

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Lieferung vsl. bis 27.11.2025

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