FYN [FYN-01]

ArtNr	20-272-192249
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	WB, IP, ICC
Clon	FYN-01
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-17F9AA
Similar products	20-272-192249
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Genway ID:	GWB-17F9AA
Clone:	FYN-01
Isotype:	IgG
Immunogen:	Recombinant fragment corresponding to amino acids 7-176 of Human Fyn.
Antigen Species:	Human
Specificity:	The antibody reacts with p59fyn (Fyn) a non receptor protein tyrosine kinase (59 kDa) which belongs to the Src family of cytoplasmic tyrosine kinases.
Target:	FYN
Localization:	Cytoplasmic
Concentration:	1 mg/ml
Purification Note:	Purified from hybridoma culture supernatant by protein A affinity chromatography. Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	ICC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted
Molecular Weight:	59 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
Function:	Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth axon guidance and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Cofactor: Manganese.
Enzyme Regulation:	Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
Subunit:	Associates through its SH3 domain to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1. Interacts with SH2D1A and SLAMF1. Interacts (via SH3 domain) with HEV ORF3 protein.
Subcellular Location:	Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
Tissue Specificity:	Isoform 1 is highly expressed in the brain isoform 2 is expressed in cells of hemopoietic lineages especially T lymphocytes.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Similarity:	Contains 1 protein kinase domain.
Similarity:	Contains 1 SH2 domain.
Similarity:	Contains 1 SH3 domain.

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Menge: 0.1 mg

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