ErbB4 [H4.77.16] antibody

C-erbB-4 is the fourth member of class I receptor kinase family (ErbB). Down regulation of ErbB-4 in estrogen receptor-positive cancer cells inhibits proliferation. Research Areas: Cancer research disease related growth factors/hormones/hormone receptors

IgG1

Human

ErbB4

Lot specific Storage

assay dependent. Functional studies (see below): assay dependent. Immunoprecipitation (with protein G): use at a concentration of 2& mu; g/mg of protein lysate. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. This antibody is not suitable for western blot (Tang C et. al). This antibody does not interfere with receptor-heregulin binding and is particularly wellsuited for immunoprecipitation of unoccupied as wellas the occupied c-erbB-4 receptor (Chen X et. al. ). It reacts withintact cells stimulates tyrosine kinase activity andefficiently stimulates internalization of c-erbB-4 (Chen X et. al. ). Cellular

Specifically binds and is activated by neuregulins NRG-2 NRG-3 heparin-binding EGF-like growth factor betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF TGF-A and amphiregulin.

Homodimer or heterodimer with each of the other ERBB receptors (Potential). Interacts with PDZ domains of DLG2 DLG3 DLG4 and the syntrophin SNTB2. Interacts with CBFA2T3 MUC1 and WWOX.

Expressed at highest levels in brain heart kidney in addition to skeletal muscle parathyroid cerebellum pituitary spleen testis and breast. Lower levels in thymus lung salivary gland and pancreas. Isoform JM-A and isoform JM-B are expressed in cerebellum but only the isoform JM-B is expressed in the heart.

Isoform JM-A is processed but not isoform JM-B. So they respectively represent cleavable and non-cleavable forms of the receptor.

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.