Cytokeratin 8 [RCK106]

GWB-5F22A7

IgG1

Human

Cytokeratin 8

0. 09% Sodium Azide Constituents: PBS

Dot: 1/100 - 1/1000. FACS: 1/100 - 1/200. ICC: Use at an assay dependent dilution. IHC-Fr: 1/100 - 1/200. WB: 1/100 - 1/1000. Myeloma: Sp2/0 Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4. 9 - 7. 8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections but are also a useful tool in cytopathology and flow cytometric assays.

Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19 interacts with DMD. Interacts with TCHP.

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).