HET/SAF-B [6F7]

ArtNr	20-272-193291
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	WB, IF, IP, IHC
Clon	6F7
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-FA4A42
Similar products	20-272-193291
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Genway ID:	GWB-FA4A42
Clone:	6F7
Isotype:	IgG1Light chain: kappa
Immunogen:	A synthetic peptide corresponding to amino acids 345-357 (PEARDSKEDGRKF) of the human HET protein.
Antigen Species:	Human
Positive Control:	HeLa MCF7
Target:	HET/SAF-B
Concentration:	1 mg/ml
Purification Note:	From hybridoma tissue culture supernatant Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	For IF: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. For WB: Use at a concentration of 1 - 2 µ g/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein
Molecular Weight:	102 Myeloma: NS1 Hsp27 ERE-TATA binding protein (HET)/ Scaffold Attachment Factor-B (SAF-B) is a member of a subset of nuclear matrix proteins that mediate the attachment of chromatin to nuclear protein complexes. The calculated molecular weight of HET/SAF-B is 102 kDa (Accession No. U72355) but on SDS PAGE gels HET/SAF-B runs as an approximately 130 kDa protein. This aberrant migration is due to a large number of charged amino acid residues.
Function:	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a \' transcriptosomal\' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation.
Subunit:	Monomer. Can form homodimers. Interacts with KHDRBS3 POLR2A SAFB2 or SFRS1 SFRS9 and SFRS10 (By similarity).
Subcellular Location:	Nucleus.
Tissue Specificity:	Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
Similarity:	Contains 1 RRM (RNA recognition motif) domain.
Similarity:	Contains 1 SAP domain.

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