NFIL6 [21A1]

ArtNr	20-272-193358
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Metabolism Diabetes Antibodies Immunoprecipitation Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IP
Clon	21A1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F84A3D
Similar products	20-272-193358
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Genway ID:	GWB-F84A3D
Clone:	21A1
Isotype:	IgG
Specificity:	Human NF-IL6.
Target:	NFIL6
Concentration:	1 mg/ml
Purification Note:	From ascitic fluid Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein
Molecular Weight:	Predicted molecular weight is 36. 1 kDa. Observed molecular weight is approximately 45-48 kDa. Myeloma: NS1 NF-IL6 is a member of the CAAT/enhancer-binding protein (C/EBP) family of transcription factors. It has been shown to directly interact with the retinoblastoma (RB) protein.
Function:	Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction inflammation and hemopoiesis. The consensus recognition site is 5\' -T[TG]NNGNAA[TG]-3\' .
Subunit:	Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha delta and gamma. Interacts with TRIM28 and PTGES2 (By similarity).
Subcellular Location:	Nucleus.
Tissue Specificity:	Expressed at low levels in the lung kidney and spleen.
Ptm:	Sumoylated by polymeric chains of SUMO2 or SUMO3.
Similarity:	Belongs to the bZIP family. C/EBP subfamily.
Similarity:	Contains 1 bZIP domain.

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Menge: 0.1 mg

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