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Neutrophil elastase [NP57]

Neutrophil elastase [NP57]

ArtNr	20-272-193399
Hersteller	GENWAY
Menge	0.5 ml
Kategorie	Oncology Antibodies Immunohistochemistry Cardiovascular Research Atherosclerosis Primary Antibodies By Organ Bone Cancer
Typ	Antibody
Applikationen	IHC
Clon	NP57
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-8F72C4
Similar products	20-272-193399
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Genway ID:	GWB-8F72C4
Clone:	NP57
Isotype:	IgG1
Immunogen:	Human Neutrophil Granule Proteins
Antigen Species:	Human
Target:	Neutrophil elastase
Localization:	Cytoplasmic
Concentration:	Lot specific and is staed on the vial Storage
Buffer:	Phosphate-buffered saline pH 7. 2 containing 0. 2% BSA and 0. 09% sodium azide
Application Note:	IHC: Prolonged fixation in buffered formalin can destroy the epitope. The antibody may be used at a dilution of 1:50 to 1:150 with AutoProbe III (). Dilute according to the particular application being used. In general the 0. 05M Borate pH 8. 0 containing 0. 15M Sodium Chloride 0. 05% Sodium Azide is a good diluent to use with most antibodies. The optimal conditions should be determined by the individual laboratory. Cellular
Localization:	Cytoplasmic This antibody reacts with human neutrophil elastase a neutral protease which plays a role in microbial killing and in initiating tissue injury. This antibody recognizes neutrophils and their precursors. This antigen is sharply localized in individual myeloid cells.
Function:	Modifies the functions of natural killer cells monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Catalytic Activity:	Hydrolysis of proteins including elastin. Preferential cleavage: Val-\|-Xaa & gt; Ala-\|-Xaa.
Subunit:	Interacts with NOTCH2NL.
Tissue Specificity:	Bone marrow cells.
Disease:	Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia affected individuals are at risk for opportunistic infection. Monocytes platelets lymphocytes and reticulocytes also cycle with the same frequency.
Disease:	Defects in ELA2 are the cause of autosomal dominant severe congenital neutropenia type 1 (SCN1) [MIM:202700]. Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0. 5 x 10(9)/l and early onset of severe bacterial infections.
Similarity:	Belongs to the peptidase S1 family. Elastase subfamily [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

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