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Actin smooth muscle [1A4] (FITC)

Actin smooth muscle [1A4] (FITC)

ArtNr	20-272-193547
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunofluorescence Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Applikationen	IF
Clon	1A4
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2DAF68
Similar products	20-272-193547
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Genway ID:	GWB-2DAF68
Clone:	1A4
Isotype:	IgG2aLight chain: kappa
Immunogen:	The N-terminal decapeptide of alpha-smooth muscle actin
Specificity:	This antibody reacts with the alpha-smooth muscle isoform of actin. It does not react with actin from fibroblasts (beta- and gamma-cytoplasmic) striated muscle (alpha-sarcomeric) and myocardium (alpha-myocardial).
Positive Control:	Bowel
Target:	Actin smooth muscle
Localization:	Cytoplasmic
Conjugation:	FITCConjugation
Note:	FITC Fluorochrome/Protein Abs. Ratio:495nm/280nm=0. 7
Concentration:	Lot specific and is stated on the vial Storage
Buffer:	50 mM potassium phosphate 150 mM Sodium Chloride 10mg/ml BSA carrier polysaccharides and 0. 05% Sodium Azide pH 7. 2.
Application Note:	For IF: Use at 10-20 µ g/ml for 2 hours at room temperature. For IF: paraffin-embedded or frozen sections as well as on cell smears can be used. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic Smooth muscle actin is expressed in normal smooth muscle and in myoepithelial cells and also in tumours derived from these cells. Actins are involved in maintaining the structure and integrity of a cell as well as cell motility. They are highly conserved proteins and make up the majority of the contractile apparatus. To date six different actin isoforms have been described.
Function:	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit:	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular Location:	Cytoplasm cytoskeleton.
Miscellaneous:	In vertebrates 3 main groups of actin isoforms alpha beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Similarity:	Belongs to the actin family.

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Menge: 0.1 mg

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