CD24 [-3/14]

ArtNr	20-272-193708
Hersteller	GENWAY
Menge	2 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	IHC
Clon	-3/14
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F09039
Similar products	20-272-193708
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Genway ID:	GWB-F09039
Clone:	-3/14
Isotype:	IgM
Immunogen:	Mouse B cells (in vivo stimulated/purified)
Antigen Species:	Mouse
Specificity:	This product recognizes mouse CD24 (expressed on thymocytes B cells erythrocytes neural cells) and aggregates LPS stimulated B-cell blasts not resting cells.
Target:	CD24
Concentration:	Tissue culture supernatant Storage
Buffer:	0. 2M Tris/HCl pH 7. 4 containing 5-10% fetal calf serum
Application Note:	For FACS: Use at a suggested dilution of 1:2 - 1:10. For IHC-Fr: Use at an assay dependent dilution. Not suitable for use in IHC-P IHC-R and WB. Not tested in other applications. Optimal concentrations/dilutions should be determined by the researcher. Myeloma: Spleen cells from an immunised Wistar rat were fused with cells of the SP2/0-Ag14 mouse myeloma cell line
Function:	Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells and prevents their terminal differentiation into antibody-forming cells.
Subunit:	Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line LYN in the erythroleukemia cell line K562 and in Burkitt\' s lymphoma.
Subcellular Location:	Cell membrane; Lipid-anchor GPI-anchor.
Tissue Specificity:	B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Induction:	Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.
Ptm:	Extensively O-glycosylated.
Disease:	Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
Similarity:	Belongs to the CD24 family.

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