Cytokeratin 5 6 + 18 [LP34]

ArtNr	20-272-193799
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Antibodies Cell Biology Cytoskeleton Immunohistochemistry Primary Antibodies Intermediate filaments By Organ Bladder Cancer
Typ	Antibody
Applikationen	IHC
Clon	LP34
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-54EB2F
Similar products	20-272-193799
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Genway ID:	GWB-54EB2F
Clone:	LP34
Isotype:	IgG1
Immunogen:	Detergent-insoluble fraction of psoriatic human epidermis
Antigen Species:	Human
Specificity:	Human cytokeratin 5 6 and 18 - The antibody has a broad reactivity with epithelial tissues ranging from simple glandular epithelial to stratified squamous epithelial.
Positive Control:	Skin
Target:	Cytokeratin 5 6 + 18 Storage
Buffer:	Phosphate-buffered saline containing 15mM sodium azide
Application Note:	For IHC-Fr and IHC-P: Use at a dilution of 1:50 - 1:150. Not tested in other applications. Optimal concentrations/dilutions should be determined by the researcher. #This product requires protein digestion pre-treatment of paraffin sections e. g. trypsin. * In frozen sections MCA1867 recognises cytokeratin 5 6 and 18 with equal intensity but staining of cytokeratin 18 in paraffin-embedded tissues may be variable. Myeloma: Spleen cells from immunised mice were fused with cells of the mouse p3-NSI-Ag4. 1 myeloma cell line.
Subunit:	Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP.
Disease:	Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering milia formation dystrophic nails and mucous membrane involvement.
Disease:	Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema (EBSMCE) [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands feet and legs but spare nails ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS with no evidence of tonofilament clumping.
Disease:	Defects in KRT5 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Disease:	Defects in KRT5 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type althought it is less severe.
Disease:	Defects in KRT5 are the cause of epidermolysis bullosa simplex with mottled pigmentation (MP-EBS) [MIM:131960]. MP-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and \' mottled\' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
Disease:	Defects in KRT5 are the cause of Dowling-Degos disease (DDD) [MIM:179850]; also known as Dowling-Degos-Kitamura disease or reticulate acropigmentation of Kitamura. DDD is an autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.
Miscellaneous:	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Similarity:	Belongs to the intermediate filament family.

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