TOLL-LIKE RECEPTOR 4 (TLR4. CD284)

HTA125

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88 TIRAP and TRAF6 leading to NF-kappa-B activation cytokine secretion and the inflammatory response (By similarity).

Membrane; Single-pass type I membrane protein (By similarity).

Belongs to the Toll-like receptor family.

Contains 1 TIR domain. Summary: receptor that functions as the major upstream sensor for hemorrhagic shock and lipopolysaccharide [RGD]. [1] Yu M. Shao D. Yang J. Feng S. and Xu J. et al. Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats[2] Mackern-Oberti J. P. Maccioni M. Cuffini C. Gatti G. and Rivero V. E. Susceptibility of prostate epithelial cells to Chlamydia muridarum infection and their role in innate immunity by recruitment of intracellular Toll-like receptors 4 and 2 and MyD88 to the inclusion[3] Quintar A. A. Roth F. D. De Paul A. L. Aoki A. and Maldonado C. A. et al. Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells[4] Jilling T. Simon D. Lu J. Meng F. J. Li D. Schy R. Thomson R. B. Soliman A. Arditi M. and Caplan M. S. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis[5] Hayashi T. Kishiwada M. Fujii K. Yuasa H. Nishioka J. Ido M. Gabazza E. C. and Suzuki K. Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4[6] Frantz S. Kobzik L. Kim Y. -D. Fukazawa R. Medzhitov R. Lee R. T. Kelly R. A. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.