A kinase (PRKA) anchor protein 8 (AKAP8)

GWB-348321

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).

Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.

Belongs to the AKAP95 family. Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This protein is a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA. [1] Olsen J. V. Blagoev B. Gnad F. Macek B. Kumar C. Mortensen P. and Mann M. Global in vivo and site-specific phosphorylation dynamics in signaling networks[2] Beausoleil S. A. Villen J. Gerber S. A. Rush J. and Gygi S. P. et al. A probability-based approach for high-throughput protein phosphorylation analysis and site localization[3] Kamada S. Kikkawa U. Tsujimoto Y. and Hunter T. et al. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association[4] Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. and Gygi S. P. Large-scale characterization of HeLa cell nuclear phosphoproteins[5] Grimwood J. Gordon L. A. Olsen A. Terry A. Schmutz J. Lamerdin J. Hellsten U. Goodstein D. Couronne O. et al. The DNA sequence and biology of human chromosome 19[6] Eide T. Coghlan V. Oerstavik S. Holsve C. Solberg R. Skaelhegg B. S. Lamb N. J. C. Langeberg L. Fernandez A. Scott J. D. et al. Molecular cloning chromosomal localization and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein AKAP95. [7] Grimwood J. Gordon L. A. Olsen A. S. Terry A. Schmutz J. Lamerdin J. E. Hellsten U. Goodstein D. Couronne O. Tran-Gyamfi M. et al. The DNA sequence and biology of human chromosome 19. [8] Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. Gygi S. P. Large-scale characterization of HeLa cell nuclear phosphoproteins. [9] Olsen J. V. Blagoev B. Gnad F. Macek B. Kumar C. Mortensen P. Mann M. Global in vivo and site-specific phosphorylation dynamics in signaling networks. [10] Beausoleil S. A. Villen J. Gerber S. A. Rush J. Gygi S. P. A probability-based approach for high-throughput protein phosphorylation analysis and site localization.