Collagen Type V

ArtNr	20-511-240476
Hersteller	GENWAY
Menge	0,1 mg
Kategorie	Antibodies Cell Biology Cell Stainings ECM Primary Antibodies
Typ	Antibody
Clon	1E2-E4
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AD50A4
Similar products	20-511-240476
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Genway ID:	GWB-AD50A4
Isotype:	IgG2a
Clone:	1E2-E4Host Animal: Mouse
Immunogen:	Collagen. Type V
Specificity:	Displays high affinity for human. ovine. bovine. porcine. canine and kangaroo Type V Collagens. Displays moderate affinity for rabbit Type V collagen. Does not cross-react with Collagen Types I. III and VI or connective tissue proteins (elastin. fibronectin and laminin).
Type of Product:	Monoclonal Antibodies to Collagens and Extracellular Matrix Proteins
Concentration:	1mg/mlPreservatives: Bronidox
Buffer:	50mM Tris Acetate 150mM Sodium Chloride pH 4. 5Applications Notes : Detection of Collagen Type V by ELISA Immunohistochemistry (1-3) and Immunoblotting. (2 4).
Note:	Some Collagen samples can be contaminated with other Collagen Types. When purified Collagen is used in an application the purity of the Collagen sample should be verified by SDS-PAGE to minimize the risk of false positives. MAb to Collagen Type V. Monoclonal Antibody to Collagen Type V
Function:	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA heparan sulfate thrombospondin heparin and insulin.
Subunit:	Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V) one alpha 2(V) and one alpha 3(V) chains in placenta. Interacts with CSPG4.
Subcellular Location:	Secreted extracellular space extracellular matrix (By similarity).
Ptm:	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Ptm:	Sulfated on 40% of tyrosines.
Disease:	Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome.
Disease:	Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis.
Similarity:	Belongs to the fibrillar collagen family.
Similarity:	Contains 1 laminin G-like domain.
Similarity:	Contains 1 TSP N-terminal (TSPN) domain.

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