IgA1

ArtNr	20-511-241270
Hersteller	GENWAY
Menge	1 mg
Kategorie	Oncology Antibodies ELISA Secondary Antibodies By Organ Lymphatic System Cancer
Typ	Antibody
Applikationen	ELISA
Clon	3C10
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2DC4C1
Similar products	20-511-241270
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Genway ID:	GWB-2DC4C1
Isotype:	IgG1
Clone:	3C10Host Animal: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Immunogen:	IgA from human colostrum
Specificity:	Alpha-1-subclass specific. IgA1 Relatively high affinity. No allotype restriction.
Type of Product:	Monoclonal Antibodies to Human Immunoglobulins
Concentration:	3. 0mg/ml (OD280nm E0. 1% = 1. 4)Preservatives: NaN3
Buffer:	PBS pH 7. 4Applications Notes : Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to IgA1. Monoclonal Antibody to Immunoglobulin A1 (IgA1)
Function:	Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Subunit:	Monomeric or polymeric.
Ptm:	3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
Disease:	A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1; 14)(q21; q32) that forms a FCRL4-IGHA1 fusion protein.
Similarity:	Contains 3 Ig-like (immunoglobulin-like) domains.

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Menge: 1 mg

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