Vitronectin

ArtNr	20-511-242083
Hersteller	GENWAY
Menge	1mg
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies Cell Biology Cell Stainings ECM Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Clon	BDI215
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E72524
Similar products	20-511-242083
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Genway ID:	GWB-E72524
Isotype:	IgG2a
Clone:	BDI215Host Animal: Mouse. Hybridization of NS-1myeloma cells with spleen cells from Balb/c mice.
Specificity:	Vitronectin
Type of Product:	Monoclonal Antibodies to Platelets and Hemostasis Antigens
Concentration:	1mg/ml (prior to lyophilization)Preservatives: NaN3
Buffer:	Lyophilized from 10mM Sodium phosphate 0. 15M Sodium chloride pH 7. 4Applications Notes : Detection of human Vitronectin by ELISA or immunoblotting. Purification of plasma Vitronectin when coupled to sepharose. Recommended use: 1?5ug/ml. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Vitronectin. Monoclonal Antibody to Human Vitronectin (VN)
Function:	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Function:	Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit:	Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
Subcellular Location:	Secreted extracellular space.
Tissue Specificity:	Plasma.
Domain:	The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Ptm:	Sulfated on 2 tyrosine residues.
Ptm:	N- and O-glycosylated (By similarity).
Ptm:	Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
Ptm:	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:	Contains 4 hemopexin-like domains.
Similarity:	Contains 1 SMB (somatomedin-B) domain.

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Menge: 1mg

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Lieferung vsl. bis 11.09.2025

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