Fibronectin

ArtNr	20-511-242225
Hersteller	GENWAY
Menge	1 mg
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Cell Biology Cell Movement Cell Adhesion Cell Stainings ECM Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Clon	1601
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3B5958
Similar products	20-511-242225
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Genway ID:	GWB-3B5958
Isotype:	IgG1
Clone:	1601Host Animal: Mouse. Hybridization of P3X63-Ag8. 653myeloma cells with spleen cells from Balb/c mice.
Immunogen:	Human plasma fibronectin
Specificity:	No cross reactivity with alpha1-acid glycoprotein. serum albumin or other serum proteins.
Type of Product:	Monoclonal Antibodies to Proteins and Bioactive Peptides
Concentration:	Lot specific and is stated on n the vialPreservatives: 0. 09% sodium azide
Buffer:	0. 015M Potassium phosphate buffer 0. 15M Sodium chloride pH 7. 2Applications Notes : Specific methodologies have not been tested using this product.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Fibronectin. Monoclonal Antibody to Human Fibronectin
Function:	Fibronectins bind cell surfaces and various compounds including collagen fibrin heparin DNA and actin. Fibronectins are involved in cell adhesion cell motility opsonization wound healing and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
Subunit:	Mostly heterodimers or multimers of alternatively spliced variants connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1 AMBP TNR LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity).
Subcellular Location:	Secreted extracellular space extracellular matrix.
Tissue Specificity:	Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms) made by fibroblasts epithelial and other cell types is deposited as fibrils in the extracellular matrix. Ugl-Y1 Ugl-Y2 and Ugl-Y3 are found in urine. Developmental Stage: Ugl-Y1 Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
Ptm:	Sulfated.
Ptm:	It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
Ptm:	Forms covalent cross-links mediated by a transglutaminase such as F13A or TGM2 between a glutamine and the epsilon-amino group of a lysine residue forming homopolymers and heteropolymers (e. g. fibrinogen-fibronectin collagen-fibronectin heteropolymers).
Disease:	Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria microscopic hematuria and hypertension that leads to end-stage renal failure in the second to fifth decade of life.
Similarity:	Contains 12 fibronectin type-I domains.
Similarity:	Contains 2 fibronectin type-II domains.
Similarity:	Contains 16 fibronectin type-III domains.

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Menge: 1 mg

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