Vimentin

ArtNr	20-512-300085
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Development Antibodies Cell Biology Cytoskeleton Primary Antibodies Intermediate filaments By Organ Skin Cancer Stem Cell Markers
Typ	Antibody
Clon	RV203
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-A7A1D3
Similar products	20-512-300085
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Genway ID:	GWB-A7A1D3
Subclass:	IgG1
Clone:	RV203
Specificity:	RV203 reacts exclusively with vimentin. which is expressed in mesenchymal cells and mesenchymal derived tumors e. g. lymphoma. sarcoma and melanoma. RV203 is suitable for immunoblotting. immunocytochemistry. immunohistochemistry on frozen tissues and flow cytometry. Optimal antibody dilution should be determined by titration; recommended range is 1:100 ? 1:200 for flow cytometry. and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent. and 1:100 ? 1:1000 for immunoblotting applications. Product
Note:	Each vial contains 100 ?l 1 mg/ml purified antibody in PBS containing 0. 09% sodium azide. Vimentin (57 kDa) is the intermediate filament protein (IFP) of mesenchymal cells. This IFP however often deviates from the tissue-specific and developmentally regulated pattern of expression. Besides its typical expression in most cultured cells. vimentin is also expressed together with several other IFPs during early stages of development. As differentiation proceeds. vimentin is exchanged for the tissue-specific intermediate filament type. Also in cancers. vimentin is often expressed in addition to the tissue-specific IFP.
Function:	Vimentins are class-III intermediate filaments found in various non-epithelial cells especially mesenchymal cells.
Subunit:	Homopolymer. Component of a complex composed at least of ACTB AP2M1 AP2A1 AP2A2 MEGF10 and VIM. Interacts with HCV core protein.
Tissue Specificity:	Highly expressed in fibroblasts some expression in T- and B-lymphocytes and little or no expression in Burkitt\' s lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
Ptm:	One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division at which time vimentin filaments are significantly reorganized.
Similarity:	Belongs to the intermediate filament family. 1. Schaart. G. Pieper. F. R. Kuijpers. H. J. Bloemendal. H. and Ramaekers. F. C. (1991). Baby hamster kidney (BHK-21/C13) cells can express striated muscle type proteins. Differentiation 46. 105-15.

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Menge: 0.1 mg

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Lieferung vsl. bis 27.11.2025

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