CD18


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies By Organ Skin Cancer
Typ	Antibody
Specific against	other
Clon	YTS213. 1
Applikationen	FC, IP, IHC
Menge	0.025 mg
ArtNr	20-783-310012
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-E1CD97
Specificity:	CD18NCBI
Gene ID:	16414
Specificity:	CD18
Clone:	YTS213. 1
Immunogen:	Mouse spleen cells
Fusion Partner:	Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1. 2. 3 myeloma cell line.
Specificity Note:	Mouse CD18 (LFA-1 family b chain) is expressed on most leucocytes YTS 213. 1 does not block LFA-1 mediated T-cell activation in vitro. The antibody precipitates an antigen of 95-180kD.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/25
Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Subunit:	Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
Disease:	Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Similarity:	Belongs to the integrin beta chain family.
Similarity:	Contains 1 VWFA domain. 1. Madrid. S. et al. (1983) Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions. LFA-1 and Mac-1.

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Menge: 0.025 mg

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