CD95


ArtNr	20-783-310108
Hersteller	GENWAY
Menge	0.025 mg
Kategorie	Oncology Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC, IP
Clon	LOB 3/11
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D3B2C0
Similar products	20-783-310108
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Genway ID:	GWB-D3B2C0
Specificity:	CD95NCBI
Gene ID:	355
Isotype:	IgG1
Clone:	LOB 3/11
Immunogen:	Fusion protein comprising extracellular domain of human Fas linked to human Fc
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSI myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/50 - 1/100Immunoprecipitation - 20ug/ml
Function:	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Subunit:	Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B.
Subcellular Location:	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 2: Secreted.
Subcellular Location:	Isoform 3: Secreted.
Subcellular Location:	Isoform 4: Secreted.
Subcellular Location:	Isoform 5: Secreted.
Subcellular Location:	Isoform 6: Secreted.
Tissue Specificity:	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Domain:	Contains a death domain involved in the binding of FADD and maybe to other cytosolic adapter proteins.
Disease:	Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
Similarity:	Contains 1 death domain.
Similarity:	Contains 3 TNFR-Cys repeats.

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