CD151


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Specific against	other
Clon	11G5a
Applikationen	FC
Menge	0.025 mg
ArtNr	20-783-310179
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-7DF04D
Specificity:	CD151NCBI
Gene ID:	977
Specificity:	CD151
Clone:	11G5a
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the X63. Ag8. 653 mouse myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
Function:	Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
Subunit:	Interacts with integrins alpha3beta1 alpha5beta1 alpha3beta1 and alpha6beta4 with CD9 and CD181.
Subcellular Location:	Membrane; Multi-pass membrane protein.
Tissue Specificity:	Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells with a higher level of expression in erythroid precursors than on mature erythrocytes.
Induction:	By HTLV-1.
Polymorphism:	CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.
Disease:	Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis epidermolysis bullosa deafness and beta-thalassemia minor.
Similarity:	Belongs to the tetraspanin (TM4SF) family. 1. Yauch. R. L. et al. (1998) Highly stoichiometric. stable. and specific association of integrin alpha 3 beta 1 with CD151 provides a major link to phosphatidylinositol 4-kinase. and may regulate cell migration. 2. Crew. V. K. et al. (2004) CD151. the first member of the tetraspanin (TM4) superfamily detected on erythrocytes. is essential for the correct assembly of human basement membranes in kidney and skin.

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Menge: 0.025 mg

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Lieferung vsl. bis 30.05.2024

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