nm23-H1


Hersteller	GENWAY
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Specific against	other
Clon	37. 6
Applikationen	IHC
Menge	0.1 ml
ArtNr	20-783-310181
eClass 6.1	32160702
eClass 9.0	32160702
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Genway ID:	GWB-9B73E5
Specificity:	nm23-H1NCBI
Gene ID:	4830
Specificity:	nm23-H1
Clone:	37. 6
Immunogen:	Nucleoside diphosphate kinase A prepared from human erythrocytes
Fusion Partner:	Spleen cells from immunised mice were fused with cells of the mouse X63-Ag8-653 myeloma cell line
Specificity Note:	This product recognises human nm23-H1 protein also known as nucleoside diphosphate kinase A (NDPK-A). There is minor cross-reactivity with the homologous protein NDPK-B (nm23-H2). nm23 expression has been reported to correlate with improved prognosis in mammary carcinoma. The protein is implicated as a metastasis suppressor and expression is linked with less aggressive forms of this disease.
Immunohistology:	This product does not require protein digestion of paraffin embedded sections prior to staining This product does not require antigen retrieval using heat treatment prior to staining of paraffin sectionsHistology: A high proportion of breast carcinomas are positive
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Dilution:	Suggested
Dilution:	Immunohistology - Frozen - 1/100 - 1/250Immunohistology - Paraffin - 1/100 - 1/250
Function:	Major role in the synthesis of nucleoside triphosphates other than ATP.
Catalytic Activity:	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. Cofactor: Magnesium.
Subunit:	Hexamer of two different chains: A and B (A6 A5B A4B2 A3B3 A2B4 AB5 B6). Interacts with SET and PRUNE.
Subcellular Location:	Cytoplasm. Nucleus.
Tissue Specificity:	Expressed in lung carcinoma cell lines but not in normal lung tissues.
Ptm:	The N-terminus is blocked.
Disease:	This protein is found in reduced amount in tumor cells of high metastatic potential. Somatic mutations of NME1 are found in neuroblastoma. Increased NME1 in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors. May therefore have distinct if not opposite roles in different tumors.
Similarity:	Belongs to the NDK family. 1. Sawan. A. et al. (1994) NDP-K/nm23 expression in human breast cancer in relation to relapse. survival. and other prognostic factors: an immunohistochemical study. 2. Sastre-Garau. X. et al. (1992) Nucleoside diphosphate kinase/nm23 expression in breast cancer: lack of correlation with lymph node metastasis.

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