CD97


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Specific against	other
Clon	MEM-180
Applikationen	FC
Menge	25 TESTS
ArtNr	20-783-310189
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-5EBB13
Specificity:	CD97NCBI
Gene ID:	976
Specificity:	CD97
Clone:	MEM-180
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells or 100ul whole bloodSuggested
Dilution:	Flow Cytometry - Neat
Function:	Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).
Subunit:	Forms a heterodimer consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.
Subcellular Location:	Cell membrane; Multi-pass membrane protein.
Subcellular Location:	CD97 antigen subunit alpha: Secreted extracellular space.
Tissue Specificity:	Broadly expressed found on most hematopoietic cells including activated lymphocytes monocytes macrophages dendritic cells and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid colorectal gastric esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid.
Induction:	Rapid up-regulation during lymphocyte activation.
Domain:	The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
Domain:	Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Ptm:	Proteolytically cleaved into 2 subunits an extracellular alpha subunit and a seven-transmembrane subunit (By similarity).
Similarity:	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].
Similarity:	Contains 5 EGF-like domains.
Similarity:	Contains 1 GPS domain. 1. Steinert. M. et al. (2002) Expression and regulation of CD97 in colorectal carcinoma cell lines and tumour tissues.

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Menge: 25 TESTS

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