CD41

CD41NCBI

CD41

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Flow Cytometry - Neat

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.

Isoform 1 and isoform 2 were identified in platelets and megakaryocytes but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls) have detectable amounts of fibrinogen and have low or moderate clot retraction capability. The platelets of GT \' variants\' have normal or near normal (60-100%) expression of dysfunctional receptors.

Contains 7 FG-GAP repeats. 1. Nieswandt. B. et al. (1999) Acute Systemic Reaction and Lung Alterations Induced by an Antiplatelet Integrin gpIIb/IIIa Antibody in Mice.